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Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers

BACKGROUND: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. MATERIAL/METHODS: A total of 26 peopl...

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Autores principales: Seyithanoğlu, Mehmet Hakan, Abdallah, Anas, Dündar, Tolga Turan, Kitiş, Serkan, Aralaşmak, Ayşe, Papaker, Meliha Gündağ, Sasani, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252049/
https://www.ncbi.nlm.nih.gov/pubmed/30447152
http://dx.doi.org/10.12659/MSM.911475
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author Seyithanoğlu, Mehmet Hakan
Abdallah, Anas
Dündar, Tolga Turan
Kitiş, Serkan
Aralaşmak, Ayşe
Papaker, Meliha Gündağ
Sasani, Hadi
author_facet Seyithanoğlu, Mehmet Hakan
Abdallah, Anas
Dündar, Tolga Turan
Kitiş, Serkan
Aralaşmak, Ayşe
Papaker, Meliha Gündağ
Sasani, Hadi
author_sort Seyithanoğlu, Mehmet Hakan
collection PubMed
description BACKGROUND: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. MATERIAL/METHODS: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). RESULTS: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. CONCLUSIONS: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposure.
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spelling pubmed-62520492018-12-13 Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers Seyithanoğlu, Mehmet Hakan Abdallah, Anas Dündar, Tolga Turan Kitiş, Serkan Aralaşmak, Ayşe Papaker, Meliha Gündağ Sasani, Hadi Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. MATERIAL/METHODS: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). RESULTS: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. CONCLUSIONS: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposure. International Scientific Literature, Inc. 2018-11-17 /pmc/articles/PMC6252049/ /pubmed/30447152 http://dx.doi.org/10.12659/MSM.911475 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Seyithanoğlu, Mehmet Hakan
Abdallah, Anas
Dündar, Tolga Turan
Kitiş, Serkan
Aralaşmak, Ayşe
Papaker, Meliha Gündağ
Sasani, Hadi
Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers
title Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers
title_full Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers
title_fullStr Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers
title_full_unstemmed Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers
title_short Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers
title_sort investigation of brain impairment using diffusion-weighted and diffusion tensor magnetic resonance imaging in experienced healthy divers
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252049/
https://www.ncbi.nlm.nih.gov/pubmed/30447152
http://dx.doi.org/10.12659/MSM.911475
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