Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease

Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement pathway. Moreover, recent evidence points towards a key role played by...

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Autores principales: Luchena, Celia, Zuazo-Ibarra, Jone, Alberdi, Elena, Matute, Carlos, Capetillo-Zarate, Estibaliz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252206/
https://www.ncbi.nlm.nih.gov/pubmed/30533998
http://dx.doi.org/10.1155/2018/2530414
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author Luchena, Celia
Zuazo-Ibarra, Jone
Alberdi, Elena
Matute, Carlos
Capetillo-Zarate, Estibaliz
author_facet Luchena, Celia
Zuazo-Ibarra, Jone
Alberdi, Elena
Matute, Carlos
Capetillo-Zarate, Estibaliz
author_sort Luchena, Celia
collection PubMed
description Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement pathway. Moreover, recent evidence points towards a key role played by glial cells in synapse loss during AD. However, further contribution of glial cells and the role of neurons to synapse pathology in AD remain not well understood. This review is aimed at comprehensively reporting the source and/or cellular localization in the CNS—in microglia, astrocytes, or neurons—of the triggering components (C1q, C3) of the classical complement pathway involved in synapse pruning in development, adulthood, and AD.
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spelling pubmed-62522062018-12-10 Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease Luchena, Celia Zuazo-Ibarra, Jone Alberdi, Elena Matute, Carlos Capetillo-Zarate, Estibaliz Mediators Inflamm Review Article Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement pathway. Moreover, recent evidence points towards a key role played by glial cells in synapse loss during AD. However, further contribution of glial cells and the role of neurons to synapse pathology in AD remain not well understood. This review is aimed at comprehensively reporting the source and/or cellular localization in the CNS—in microglia, astrocytes, or neurons—of the triggering components (C1q, C3) of the classical complement pathway involved in synapse pruning in development, adulthood, and AD. Hindawi 2018-11-11 /pmc/articles/PMC6252206/ /pubmed/30533998 http://dx.doi.org/10.1155/2018/2530414 Text en Copyright © 2018 Celia Luchena et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Luchena, Celia
Zuazo-Ibarra, Jone
Alberdi, Elena
Matute, Carlos
Capetillo-Zarate, Estibaliz
Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
title Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
title_full Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
title_fullStr Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
title_full_unstemmed Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
title_short Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
title_sort contribution of neurons and glial cells to complement-mediated synapse removal during development, aging and in alzheimer's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252206/
https://www.ncbi.nlm.nih.gov/pubmed/30533998
http://dx.doi.org/10.1155/2018/2530414
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