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Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are emerging as a promising source for bone regeneration in the treatment of bone defects. Previous studies have reported the ability of WJ-MSCs to be induced into the osteogenic lineage. The purpose of this review was to systematically a...

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Autores principales: Ansari, Ayu Suraya, Yazid, Muhammad Dain, Sainik, Nur Qisya Afifah Veronica, Razali, Rabiatul Adawiyah, Saim, Aminuddin Bin, Idrus, Ruszymah Bt Hj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252214/
https://www.ncbi.nlm.nih.gov/pubmed/30534156
http://dx.doi.org/10.1155/2018/2406462
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author Ansari, Ayu Suraya
Yazid, Muhammad Dain
Sainik, Nur Qisya Afifah Veronica
Razali, Rabiatul Adawiyah
Saim, Aminuddin Bin
Idrus, Ruszymah Bt Hj
author_facet Ansari, Ayu Suraya
Yazid, Muhammad Dain
Sainik, Nur Qisya Afifah Veronica
Razali, Rabiatul Adawiyah
Saim, Aminuddin Bin
Idrus, Ruszymah Bt Hj
author_sort Ansari, Ayu Suraya
collection PubMed
description Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are emerging as a promising source for bone regeneration in the treatment of bone defects. Previous studies have reported the ability of WJ-MSCs to be induced into the osteogenic lineage. The purpose of this review was to systematically assess the potential of WJ-MSC differentiation into the osteogenic lineage. A comprehensive search was conducted in Medline via Ebscohost and Scopus, where relevant studies published between 1961 and 2018 were selected. The main inclusion criteria were that articles must be primary studies published in English evaluating osteogenic induction of WJ-MSCs. The literature search identified 92 related articles, but only 18 articles met the inclusion criteria. These include two animal studies, three articles containing both in vitro and in vivo assessments, and 13 articles on in vitro studies, all of which are discussed in this review. There were two types of osteogenic induction used in these studies, either chemical or physical. The studies demonstrate that WJ-MSCs are able to differentiate into osteogenic lineage and promote osteogenesis. In light of these observations, it is suggested that WJ-MSCs can be a potential source of stem cells for osteogenic induction, as an alternative to bone marrow-derived mesenchymal stem cells.
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spelling pubmed-62522142018-12-10 Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review Ansari, Ayu Suraya Yazid, Muhammad Dain Sainik, Nur Qisya Afifah Veronica Razali, Rabiatul Adawiyah Saim, Aminuddin Bin Idrus, Ruszymah Bt Hj Stem Cells Int Review Article Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are emerging as a promising source for bone regeneration in the treatment of bone defects. Previous studies have reported the ability of WJ-MSCs to be induced into the osteogenic lineage. The purpose of this review was to systematically assess the potential of WJ-MSC differentiation into the osteogenic lineage. A comprehensive search was conducted in Medline via Ebscohost and Scopus, where relevant studies published between 1961 and 2018 were selected. The main inclusion criteria were that articles must be primary studies published in English evaluating osteogenic induction of WJ-MSCs. The literature search identified 92 related articles, but only 18 articles met the inclusion criteria. These include two animal studies, three articles containing both in vitro and in vivo assessments, and 13 articles on in vitro studies, all of which are discussed in this review. There were two types of osteogenic induction used in these studies, either chemical or physical. The studies demonstrate that WJ-MSCs are able to differentiate into osteogenic lineage and promote osteogenesis. In light of these observations, it is suggested that WJ-MSCs can be a potential source of stem cells for osteogenic induction, as an alternative to bone marrow-derived mesenchymal stem cells. Hindawi 2018-11-11 /pmc/articles/PMC6252214/ /pubmed/30534156 http://dx.doi.org/10.1155/2018/2406462 Text en Copyright © 2018 Ayu Suraya Ansari et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ansari, Ayu Suraya
Yazid, Muhammad Dain
Sainik, Nur Qisya Afifah Veronica
Razali, Rabiatul Adawiyah
Saim, Aminuddin Bin
Idrus, Ruszymah Bt Hj
Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review
title Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review
title_full Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review
title_fullStr Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review
title_full_unstemmed Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review
title_short Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review
title_sort osteogenic induction of wharton's jelly-derived mesenchymal stem cell for bone regeneration: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252214/
https://www.ncbi.nlm.nih.gov/pubmed/30534156
http://dx.doi.org/10.1155/2018/2406462
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