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1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia
BACKGROUND: Pneumonia remains the leading killer with an estimated of 922,000 fatalities or 15% of all deaths in <5-year-old children in 2013. Mortality can be reduced by providing appropriate treatment to the pathogens. The objectives of this study were to describe the causes of pneumonia that m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252409/ http://dx.doi.org/10.1093/ofid/ofy210.1286 |
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author | Lokida, Dewi Nurhayati, Nurhayati Budiman, Arif Farida, Helmia Anam, Moh Syarofil Ridho, Muhammad Rosyid Dewi, Isabella Puspa Aziz, Mochamad Helmi Kosasih, Herman Karyana, Muhammad |
author_facet | Lokida, Dewi Nurhayati, Nurhayati Budiman, Arif Farida, Helmia Anam, Moh Syarofil Ridho, Muhammad Rosyid Dewi, Isabella Puspa Aziz, Mochamad Helmi Kosasih, Herman Karyana, Muhammad |
author_sort | Lokida, Dewi |
collection | PubMed |
description | BACKGROUND: Pneumonia remains the leading killer with an estimated of 922,000 fatalities or 15% of all deaths in <5-year-old children in 2013. Mortality can be reduced by providing appropriate treatment to the pathogens. The objectives of this study were to describe the causes of pneumonia that may change after the introduction of vaccines and to identify biomarkers to differentiate between bacterial and viral infection. METHODS: A 2-year multicenter cohort study of children between 2-month–5-year old with pneumonia has been conducted in three hospitals in Indonesia since July 2017. Demographics, clinical, laboratory, radiology, treatment data, have been recorded. Blood, urine, nasopharyngeal swab, sputum/induced sputum, specimens have been collected for biomarkers, culture, molecular and serological tests. RESULTS: Three-thirty from 99 pneumonia subjects screened were enrolled in this study since July 2017. 20 (60.6%) subjects had bacterial and viral coinfection, 10 (30.3%) subjects with bacterial infection, two (6.0%) subjects with viral infection, and one (3.0%) subject had unknown etiology. Demography, clinical signs and symptoms, disease and vaccination history, laboratory, and radiological evaluation are shown in Table 1. The etiologies of pneumonia are described in Figure 1. CONCLUSION: Mixed viral and bacterial infection were predominant. Several atypical pathogens were identified. No significant different in biomarkers between viral, bacterial and mixed infection groups was found. This finding highlights the need to improve diagnostic capacity to aid clinicians in pneumonia management. [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures. |
format | Online Article Text |
id | pubmed-6252409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62524092018-11-28 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia Lokida, Dewi Nurhayati, Nurhayati Budiman, Arif Farida, Helmia Anam, Moh Syarofil Ridho, Muhammad Rosyid Dewi, Isabella Puspa Aziz, Mochamad Helmi Kosasih, Herman Karyana, Muhammad Open Forum Infect Dis Abstracts BACKGROUND: Pneumonia remains the leading killer with an estimated of 922,000 fatalities or 15% of all deaths in <5-year-old children in 2013. Mortality can be reduced by providing appropriate treatment to the pathogens. The objectives of this study were to describe the causes of pneumonia that may change after the introduction of vaccines and to identify biomarkers to differentiate between bacterial and viral infection. METHODS: A 2-year multicenter cohort study of children between 2-month–5-year old with pneumonia has been conducted in three hospitals in Indonesia since July 2017. Demographics, clinical, laboratory, radiology, treatment data, have been recorded. Blood, urine, nasopharyngeal swab, sputum/induced sputum, specimens have been collected for biomarkers, culture, molecular and serological tests. RESULTS: Three-thirty from 99 pneumonia subjects screened were enrolled in this study since July 2017. 20 (60.6%) subjects had bacterial and viral coinfection, 10 (30.3%) subjects with bacterial infection, two (6.0%) subjects with viral infection, and one (3.0%) subject had unknown etiology. Demography, clinical signs and symptoms, disease and vaccination history, laboratory, and radiological evaluation are shown in Table 1. The etiologies of pneumonia are described in Figure 1. CONCLUSION: Mixed viral and bacterial infection were predominant. Several atypical pathogens were identified. No significant different in biomarkers between viral, bacterial and mixed infection groups was found. This finding highlights the need to improve diagnostic capacity to aid clinicians in pneumonia management. [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2018-11-26 /pmc/articles/PMC6252409/ http://dx.doi.org/10.1093/ofid/ofy210.1286 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Abstracts Lokida, Dewi Nurhayati, Nurhayati Budiman, Arif Farida, Helmia Anam, Moh Syarofil Ridho, Muhammad Rosyid Dewi, Isabella Puspa Aziz, Mochamad Helmi Kosasih, Herman Karyana, Muhammad 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia |
title | 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia |
title_full | 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia |
title_fullStr | 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia |
title_full_unstemmed | 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia |
title_short | 1456. Biomarkes in Different Etiologies of Pneumonia in Pediatrics in Indonesia |
title_sort | 1456. biomarkes in different etiologies of pneumonia in pediatrics in indonesia |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252409/ http://dx.doi.org/10.1093/ofid/ofy210.1286 |
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