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Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases

To examine the morphological changes of the pituitary glands and linear growth of childhood nasopharyngeal carcinoma (NPC) cases who accepted radiotherapy. A total of 90 children (i.e., age less than 18 years) who were diagnosed as NPC at Sun Yat-sen University Cancer Center from January 2009 to Jan...

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Autores principales: Xie, Chuanbo, Li, Jiaoxing, Weng, Zijin, He, Long-Jun, Yin, Shaohan, Zhang, Jingwen, Zhang, Jing, Sun, Tao, Li, Haojiang, Liu, Yuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252907/
https://www.ncbi.nlm.nih.gov/pubmed/30510539
http://dx.doi.org/10.3389/fendo.2018.00643
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author Xie, Chuanbo
Li, Jiaoxing
Weng, Zijin
He, Long-Jun
Yin, Shaohan
Zhang, Jingwen
Zhang, Jing
Sun, Tao
Li, Haojiang
Liu, Yuying
author_facet Xie, Chuanbo
Li, Jiaoxing
Weng, Zijin
He, Long-Jun
Yin, Shaohan
Zhang, Jingwen
Zhang, Jing
Sun, Tao
Li, Haojiang
Liu, Yuying
author_sort Xie, Chuanbo
collection PubMed
description To examine the morphological changes of the pituitary glands and linear growth of childhood nasopharyngeal carcinoma (NPC) cases who accepted radiotherapy. A total of 90 children (i.e., age less than 18 years) who were diagnosed as NPC at Sun Yat-sen University Cancer Center from January 2009 to January 2016 were identified by reviewing medical records. Two radiologists reviewed and measured the pre-radiation, post-radiation, and the latest available pituitary gland heights independently. Patients' current height information was collected by telephone interviews. We compared the pituitary height differences using paired t-tests and estimated the pituitary height trajectories within each sex by mixed regression models. Height-for-age Z-score was calculated for each patient using the WHO growth reference data for 5–19 years as reference. Most of the included participants were of male sex (75.6%) and over half were diagnosed at stage IV (58.4%). Among the 90 included participants, 89 had one repeated measurement of the pituitary height and 79 had two repeated measurements of the pituitary height. Seventy six of the 89 childhood NPC participants had reduced pituitary heights after radiation and accounted for 85.4% of the whole population. The means of the pituitary heights before and after radiotherapy were 6.4 ± 1.3 mm and 5.6 ± 1.2 mm (P < 0.001), respectively. The mean of height-for-age Z-score for childhood NPC cases was significantly below zero (−0.54, 95% CI = −0.74, −0.34). We concluded that childhood NPC cases had decreased pituitary heights and stunted linear growth after radiotherapy.
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spelling pubmed-62529072018-12-03 Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases Xie, Chuanbo Li, Jiaoxing Weng, Zijin He, Long-Jun Yin, Shaohan Zhang, Jingwen Zhang, Jing Sun, Tao Li, Haojiang Liu, Yuying Front Endocrinol (Lausanne) Endocrinology To examine the morphological changes of the pituitary glands and linear growth of childhood nasopharyngeal carcinoma (NPC) cases who accepted radiotherapy. A total of 90 children (i.e., age less than 18 years) who were diagnosed as NPC at Sun Yat-sen University Cancer Center from January 2009 to January 2016 were identified by reviewing medical records. Two radiologists reviewed and measured the pre-radiation, post-radiation, and the latest available pituitary gland heights independently. Patients' current height information was collected by telephone interviews. We compared the pituitary height differences using paired t-tests and estimated the pituitary height trajectories within each sex by mixed regression models. Height-for-age Z-score was calculated for each patient using the WHO growth reference data for 5–19 years as reference. Most of the included participants were of male sex (75.6%) and over half were diagnosed at stage IV (58.4%). Among the 90 included participants, 89 had one repeated measurement of the pituitary height and 79 had two repeated measurements of the pituitary height. Seventy six of the 89 childhood NPC participants had reduced pituitary heights after radiation and accounted for 85.4% of the whole population. The means of the pituitary heights before and after radiotherapy were 6.4 ± 1.3 mm and 5.6 ± 1.2 mm (P < 0.001), respectively. The mean of height-for-age Z-score for childhood NPC cases was significantly below zero (−0.54, 95% CI = −0.74, −0.34). We concluded that childhood NPC cases had decreased pituitary heights and stunted linear growth after radiotherapy. Frontiers Media S.A. 2018-11-19 /pmc/articles/PMC6252907/ /pubmed/30510539 http://dx.doi.org/10.3389/fendo.2018.00643 Text en Copyright © 2018 Xie, Li, Weng, He, Yin, Zhang, Zhang, Sun and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Xie, Chuanbo
Li, Jiaoxing
Weng, Zijin
He, Long-Jun
Yin, Shaohan
Zhang, Jingwen
Zhang, Jing
Sun, Tao
Li, Haojiang
Liu, Yuying
Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases
title Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases
title_full Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases
title_fullStr Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases
title_full_unstemmed Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases
title_short Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases
title_sort decreased pituitary height and stunted linear growth after radiotherapy in survivors of childhood nasopharyngeal carcinoma cases
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252907/
https://www.ncbi.nlm.nih.gov/pubmed/30510539
http://dx.doi.org/10.3389/fendo.2018.00643
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