1383. In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of NOSO-502, a First-in-Class Odilorhabdin Antibiotic, Against E. coli (EC) and K. pneumoniae (KPN) in the Murine Neutropenic Thigh Model

BACKGROUND: NOSO-502 is a novel, first-in-class Odilorhabdin antibiotic targeting bacterial protein translation, with potent in vitro activity against Enterobacteriaceae including strains with MDR or CRE-phenotype. The goal of this study was to determine the PK/PD characteristics of NOSO-502 using t...

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Detalles Bibliográficos
Autores principales: Zhao, Miao, Lepak, Alexander J, Andes, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253058/
http://dx.doi.org/10.1093/ofid/ofy210.1214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253058/
http://dx.doi.org/10.1093/ofid/ofy210.1214

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