1405. Efficacy of the Human-Simulated Regimen (HSR) of Cefepime (FEP)/VNRX-5133 Combination Against Serine β-Lactamase-Producing Gram-negative Bacteria in the Neutropenic Murine Thigh Infection Model

BACKGROUND: VNRX-5133 is a new-generation β-lactamase inhibitor with potent activity against serine and metallo-β-lactamases. FEP/VNRX-5133 combination shows remarkable in vitro activity against multi-drug-resistant Gram-negative bacteria. The objective of this study was to assess the in vivo effica...

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Detalles Bibliográficos
Autores principales: Abdelraouf, Kamilia, Abuhussain, Safa Almarzoky, Nicolau, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253331/
http://dx.doi.org/10.1093/ofid/ofy210.1236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253331/
http://dx.doi.org/10.1093/ofid/ofy210.1236

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