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1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα
BACKGROUND: TNFα inhibitors are a well-known risk factor for active tuberculosis but less is known about the link between TNFα inhibitors and other mycobacterial diseases, particularly M. marinum. With the increase in use of these medications, and the trend toward more outdoors activities that inclu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253413/ http://dx.doi.org/10.1093/ofid/ofy210.1431 |
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author | Zeineddine, Nabil Tiyouh, Melissa Braun, Todd |
author_facet | Zeineddine, Nabil Tiyouh, Melissa Braun, Todd |
author_sort | Zeineddine, Nabil |
collection | PubMed |
description | BACKGROUND: TNFα inhibitors are a well-known risk factor for active tuberculosis but less is known about the link between TNFα inhibitors and other mycobacterial diseases, particularly M. marinum. With the increase in use of these medications, and the trend toward more outdoors activities that include aquatic environment exposure, focus should be on better understanding of the link between use of TNFα inhibitors and the development of a severe M. marinum infection that might require earlier diagnosis and more aggressive antibiotic therapy. METHODS: We will describe our experience with three cases of aggressive cutaneous M. marinum infection in patients taking anti-TNFα that presented to Abington Memorial Hospital in Pennsylvania between 2014 and 2017. RESULTS: Age, gender, diagnosis CONCLUSION: TNFα is not only linked to active TB, but also associated with other mycobacterial diseases including M. marinum. While CDC reports a delay of 17 months from time of onset of symptoms to establishing the diagnosis, our three cases were diagnosed much earlier. Early diagnosis relies probably on involvement of Infectious diseases specialists early in the course of the illness and the readiness in sampling of the lesions. The challenge to the clinicians remain in the safety and the timing of resuming anti TNFα treatment after M. marinum infection. DISCLOSURES: All authors: No reported disclosures. |
format | Online Article Text |
id | pubmed-6253413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62534132018-11-28 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα Zeineddine, Nabil Tiyouh, Melissa Braun, Todd Open Forum Infect Dis Abstracts BACKGROUND: TNFα inhibitors are a well-known risk factor for active tuberculosis but less is known about the link between TNFα inhibitors and other mycobacterial diseases, particularly M. marinum. With the increase in use of these medications, and the trend toward more outdoors activities that include aquatic environment exposure, focus should be on better understanding of the link between use of TNFα inhibitors and the development of a severe M. marinum infection that might require earlier diagnosis and more aggressive antibiotic therapy. METHODS: We will describe our experience with three cases of aggressive cutaneous M. marinum infection in patients taking anti-TNFα that presented to Abington Memorial Hospital in Pennsylvania between 2014 and 2017. RESULTS: Age, gender, diagnosis CONCLUSION: TNFα is not only linked to active TB, but also associated with other mycobacterial diseases including M. marinum. While CDC reports a delay of 17 months from time of onset of symptoms to establishing the diagnosis, our three cases were diagnosed much earlier. Early diagnosis relies probably on involvement of Infectious diseases specialists early in the course of the illness and the readiness in sampling of the lesions. The challenge to the clinicians remain in the safety and the timing of resuming anti TNFα treatment after M. marinum infection. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2018-11-26 /pmc/articles/PMC6253413/ http://dx.doi.org/10.1093/ofid/ofy210.1431 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Abstracts Zeineddine, Nabil Tiyouh, Melissa Braun, Todd 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα |
title | 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα |
title_full | 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα |
title_fullStr | 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα |
title_full_unstemmed | 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα |
title_short | 1603. Our Experience With M. marinum Cutaneous Infections in Three Patients Receiving Anti-TNFα |
title_sort | 1603. our experience with m. marinum cutaneous infections in three patients receiving anti-tnfα |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253413/ http://dx.doi.org/10.1093/ofid/ofy210.1431 |
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