2343. A Multicenter Study on Clinical Outcome of Symptomatic Neonatal Herpes Simplex Virus Infection in Korea

BACKGROUND: Neonatal herpes simplex virus (NHSV) infection is rare but can cause a severe disease, even death. However, data on NHSV are limited in Asia. The aim of this study was to estimate the number of NHSV infection and evaluate the characteristics of NHSV infection in Korea where seroprevalence of HSV infection in child-bearing age women is not well known. METHODS: This is the first multicenter retrospective study in 12 university hospitals in Korea. From January 2008 to December 2017, neonates ≤ 28-day old with confirmed HSV infection were identified and a chart review was performed. RESULTS: Among 12 medical centers, 16 patients were identified in six centers. Eight (50%) patients were male and median age at admission was 11.1 days (range, 0–28 days). Ten (63%) patients were positive for HSV 1 and six (37%) patients were HSV 2 positive. Four (25%) patients were classified as disseminated HSV. Eleven (69%) patients were diagnosed as central nervous system (CNS) disease. One (6%) patient had skin, eye, and/or mouth (SEM) disease. All the patients received intravenous acyclovir and median treatment duration was 19 days (range 3–68 days). Five (35%) patients received additional suppressive therapy and median treatment duration was 131.4 days. Four patients (25%) developed seizure (one in disseminated and three in CNS disease) and two of them recovered without neurologic complications. Two (12.5%) patients with disseminated disease died within 30 days from the diagnosis and one of them had a maternal history of previous genital herpetic lesion. There was no mention on maternal history of genital herpes in 10 (63%) patients in the medical records. CONCLUSION: Although not common, NHSV infection occurs in Korean babies with high 30-day mortality rate of 12.5%. Increased awareness is warranted among Korean pediatricians to take a thorough maternal history of genital herpes infection. DISCLOSURES: All Authors: Korean Society of Pediatric Infectious Diseases: Member, Research grant.