798. The Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of Anti-Tuberculosis Compounds: Demonstrated With Para-Amino Salicylic Acid and Its Analogue

BACKGROUND: Para-aminosalicylic acid (PAS) was one of the first antibiotics to be used against tuberculosis (TB) and it is still one of the last remaining drugs available to treat extensively drug-resistant (XDR) disease. Despite being on the market for decades, the mechanism of action of PAS is not...

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Detalles Bibliográficos
Autores principales: Satta, Giovanni, Witney, Adam A, Ere, Diepreye, Disney, Alex, Begum, Neelu, Canseco, Julio Ortiz, Ratledge, Colin, Boa, Andrew N, McHugh, Timothy D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
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Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253550/
http://dx.doi.org/10.1093/ofid/ofy210.805

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