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584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection

BACKGROUND: In the era of antiretroviral therapy, HIV-infected patients are living longer generating life expectancies similar to HIV uninfected individuals. Depression has been described as the most common neuropsychiatric complication among people living with HIV. Our primary aim was to examine an...

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Autores principales: Mumford, Brigid, Pirrone, Vanessa, O’Hayer, C Virginia, Dampier, William, Wigdahl, Brian, O’Loughlin, Caitlin, Amat, Maelys, Szep, Zsofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253587/
http://dx.doi.org/10.1093/ofid/ofy210.591
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author Mumford, Brigid
Pirrone, Vanessa
O’Hayer, C Virginia
Dampier, William
Wigdahl, Brian
O’Loughlin, Caitlin
Amat, Maelys
Szep, Zsofia
author_facet Mumford, Brigid
Pirrone, Vanessa
O’Hayer, C Virginia
Dampier, William
Wigdahl, Brian
O’Loughlin, Caitlin
Amat, Maelys
Szep, Zsofia
author_sort Mumford, Brigid
collection PubMed
description BACKGROUND: In the era of antiretroviral therapy, HIV-infected patients are living longer generating life expectancies similar to HIV uninfected individuals. Depression has been described as the most common neuropsychiatric complication among people living with HIV. Our primary aim was to examine any association between neurocognitive function and depression among individuals with HIV infection. Our secondary aim was to investigate any association between heightened inflammation and neurocognitive function and depression in HIV infection. METHODS: We performed a cross-sectional study among patients living with HIV who receive care at the Drexel University Partnership Comprehensive Care Practice and who participate in the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort Study. We included individuals who underwent a comprehensive neurocognitive assessment between September 1, 2013 and June 1, 2015. Chart reviews were conducted for all eligible participants to elicit diagnosis of depression based on ICD10 codes, presence of antidepressant medication and for engagement in psychiatric care Subject characteristics were described overall and by depression status. Categorical variables were evaluated using Fisher’s exact tests and continuous variables were described using Mann–Whitney U tests. RESULTS: One hundred ninety-seven participants with available neurocognitive evaluation were included, 64% male, mean age of 53 ± 7.8 and 88% African American. Overall 23% of patients had a diagnosis of depression based on medication, diagnosis code, and engagement in psychiatric care. We did not find an association between eurocognitive score and diagnosis of depression. Among individuals with available lab values for interleukin (IL)-6 and C-reactive protein (CRP) we did not find an association between level of inflammation and depression. CONCLUSION: As individuals with HIV are living longer, we are seeing a higher prevalence of comorbidities such as depression, but it is not clear what role HIV itself plays in comparison to traditional risk factors, and this needs further evaluation. In our study we did not find an association between neurocognitive impairment and depression in people living with HIV infection. DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-62535872018-11-28 584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection Mumford, Brigid Pirrone, Vanessa O’Hayer, C Virginia Dampier, William Wigdahl, Brian O’Loughlin, Caitlin Amat, Maelys Szep, Zsofia Open Forum Infect Dis Abstracts BACKGROUND: In the era of antiretroviral therapy, HIV-infected patients are living longer generating life expectancies similar to HIV uninfected individuals. Depression has been described as the most common neuropsychiatric complication among people living with HIV. Our primary aim was to examine any association between neurocognitive function and depression among individuals with HIV infection. Our secondary aim was to investigate any association between heightened inflammation and neurocognitive function and depression in HIV infection. METHODS: We performed a cross-sectional study among patients living with HIV who receive care at the Drexel University Partnership Comprehensive Care Practice and who participate in the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort Study. We included individuals who underwent a comprehensive neurocognitive assessment between September 1, 2013 and June 1, 2015. Chart reviews were conducted for all eligible participants to elicit diagnosis of depression based on ICD10 codes, presence of antidepressant medication and for engagement in psychiatric care Subject characteristics were described overall and by depression status. Categorical variables were evaluated using Fisher’s exact tests and continuous variables were described using Mann–Whitney U tests. RESULTS: One hundred ninety-seven participants with available neurocognitive evaluation were included, 64% male, mean age of 53 ± 7.8 and 88% African American. Overall 23% of patients had a diagnosis of depression based on medication, diagnosis code, and engagement in psychiatric care. We did not find an association between eurocognitive score and diagnosis of depression. Among individuals with available lab values for interleukin (IL)-6 and C-reactive protein (CRP) we did not find an association between level of inflammation and depression. CONCLUSION: As individuals with HIV are living longer, we are seeing a higher prevalence of comorbidities such as depression, but it is not clear what role HIV itself plays in comparison to traditional risk factors, and this needs further evaluation. In our study we did not find an association between neurocognitive impairment and depression in people living with HIV infection. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2018-11-26 /pmc/articles/PMC6253587/ http://dx.doi.org/10.1093/ofid/ofy210.591 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Mumford, Brigid
Pirrone, Vanessa
O’Hayer, C Virginia
Dampier, William
Wigdahl, Brian
O’Loughlin, Caitlin
Amat, Maelys
Szep, Zsofia
584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection
title 584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection
title_full 584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection
title_fullStr 584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection
title_full_unstemmed 584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection
title_short 584. Investigation of the Association Between Neurocognitive Function and Depression in HIV Infection
title_sort 584. investigation of the association between neurocognitive function and depression in hiv infection
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253587/
http://dx.doi.org/10.1093/ofid/ofy210.591
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