1531. A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 Is Safe and Immunogenic in Healthy Volunteers, Allowing for Development of a Phase II Clinical Trial in Living Donor Kidney Transplant Recipients

BACKGROUND: Cytomegalovirus (CMV) is a major pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and antiviral resistance. A safe and protective CMV vaccine is highly desirable. METHODS: HB-101 is a CMV vaccine consisting of two...

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Detalles Bibliográficos
Autores principales: Kotton, Camille Nelson, Schwendinge, Michael, Thiry, Georges, DeVos, Beatrice, Boever, Fien De, Leroux-Roels, Geert, Lilja, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253627/
http://dx.doi.org/10.1093/ofid/ofy210.1360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253627/
http://dx.doi.org/10.1093/ofid/ofy210.1360

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