Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level

Neem oil is obtained from the seeds of the tree Azadirachta indica. Its chemical composition is very complex, being rich in terpenoids and limonoids, as well as volatile sulphur modified compounds. This work focused on the evaluation of a component of the whole Neem oil obtained by methanolic extrac...

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Detalles Bibliográficos
Autores principales: Ricci, Francesca, Berardi, Valerio, Risuleo, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253829/
https://www.ncbi.nlm.nih.gov/pubmed/19127242
http://dx.doi.org/10.3390/molecules14010122
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author Ricci, Francesca
Berardi, Valerio
Risuleo, Gianfranco
author_facet Ricci, Francesca
Berardi, Valerio
Risuleo, Gianfranco
author_sort Ricci, Francesca
collection PubMed
description Neem oil is obtained from the seeds of the tree Azadirachta indica. Its chemical composition is very complex, being rich in terpenoids and limonoids, as well as volatile sulphur modified compounds. This work focused on the evaluation of a component of the whole Neem oil obtained by methanolic extraction and defined as MEX. Cytotoxicity was assessed on two different cell populations: a stabilized murine fibroblast line (3T6) and a tumor cell line (HeLa). The data presented here suggest a differential sensitivity of these two populations, the tumor line exhibiting a significantly higher sensitivity to MEX. The data strongly suggest that its toxic target is the cell membrane. In addition the results presented here imply that MEX may contain one or more agents that could find a potential use in anti-proliferative therapy.
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spelling pubmed-62538292018-11-30 Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level Ricci, Francesca Berardi, Valerio Risuleo, Gianfranco Molecules Article Neem oil is obtained from the seeds of the tree Azadirachta indica. Its chemical composition is very complex, being rich in terpenoids and limonoids, as well as volatile sulphur modified compounds. This work focused on the evaluation of a component of the whole Neem oil obtained by methanolic extraction and defined as MEX. Cytotoxicity was assessed on two different cell populations: a stabilized murine fibroblast line (3T6) and a tumor cell line (HeLa). The data presented here suggest a differential sensitivity of these two populations, the tumor line exhibiting a significantly higher sensitivity to MEX. The data strongly suggest that its toxic target is the cell membrane. In addition the results presented here imply that MEX may contain one or more agents that could find a potential use in anti-proliferative therapy. Molecular Diversity Preservation International 2008-12-31 /pmc/articles/PMC6253829/ /pubmed/19127242 http://dx.doi.org/10.3390/molecules14010122 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ricci, Francesca
Berardi, Valerio
Risuleo, Gianfranco
Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level
title Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level
title_full Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level
title_fullStr Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level
title_full_unstemmed Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level
title_short Differential Cytotoxicity of MEX: a Component of Neem Oil Whose Action Is Exerted at the Cell Membrane Level
title_sort differential cytotoxicity of mex: a component of neem oil whose action is exerted at the cell membrane level
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253829/
https://www.ncbi.nlm.nih.gov/pubmed/19127242
http://dx.doi.org/10.3390/molecules14010122
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AT risuleogianfranco differentialcytotoxicityofmexacomponentofneemoilwhoseactionisexertedatthecellmembranelevel

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