“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst

A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst(®) A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "f...

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Detalles Bibliográficos
Autores principales: Jlalia, Ibtissem, Meganem, Faouzi, Herscovici, Jean, Girard, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253830/
https://www.ncbi.nlm.nih.gov/pubmed/19169200
http://dx.doi.org/10.3390/molecules14010528
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author Jlalia, Ibtissem
Meganem, Faouzi
Herscovici, Jean
Girard, Christian
author_facet Jlalia, Ibtissem
Meganem, Faouzi
Herscovici, Jean
Girard, Christian
author_sort Jlalia, Ibtissem
collection PubMed
description A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst(®) A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
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spelling pubmed-62538302018-11-30 “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst Jlalia, Ibtissem Meganem, Faouzi Herscovici, Jean Girard, Christian Molecules Communication A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst(®) A21•CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale. Molecular Diversity Preservation International 2009-01-22 /pmc/articles/PMC6253830/ /pubmed/19169200 http://dx.doi.org/10.3390/molecules14010528 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Jlalia, Ibtissem
Meganem, Faouzi
Herscovici, Jean
Girard, Christian
“Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
title “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
title_full “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
title_fullStr “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
title_full_unstemmed “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
title_short “Flash” Solvent-free Synthesis of Triazoles Using a Supported Catalyst
title_sort “flash” solvent-free synthesis of triazoles using a supported catalyst
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253830/
https://www.ncbi.nlm.nih.gov/pubmed/19169200
http://dx.doi.org/10.3390/molecules14010528
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AT girardchristian flashsolventfreesynthesisoftriazolesusingasupportedcatalyst

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