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Properties of an Oral Preparation Containing a Chitosan Salt

The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present tog...

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Autores principales: Murata, Yoshifumi, Kodama, Youko, Hirai, Daijirou, Kofuji, Kyouko, Kawashima, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253835/
https://www.ncbi.nlm.nih.gov/pubmed/19223823
http://dx.doi.org/10.3390/molecules14020755
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author Murata, Yoshifumi
Kodama, Youko
Hirai, Daijirou
Kofuji, Kyouko
Kawashima, Susumu
author_facet Murata, Yoshifumi
Kodama, Youko
Hirai, Daijirou
Kofuji, Kyouko
Kawashima, Susumu
author_sort Murata, Yoshifumi
collection PubMed
description The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehicle containing CS-CMP, might be a useful agent with which to treat hyperlipidemia.
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spelling pubmed-62538352018-11-30 Properties of an Oral Preparation Containing a Chitosan Salt Murata, Yoshifumi Kodama, Youko Hirai, Daijirou Kofuji, Kyouko Kawashima, Susumu Molecules Communication The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehicle containing CS-CMP, might be a useful agent with which to treat hyperlipidemia. Molecular Diversity Preservation International 2009-02-13 /pmc/articles/PMC6253835/ /pubmed/19223823 http://dx.doi.org/10.3390/molecules14020755 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Murata, Yoshifumi
Kodama, Youko
Hirai, Daijirou
Kofuji, Kyouko
Kawashima, Susumu
Properties of an Oral Preparation Containing a Chitosan Salt
title Properties of an Oral Preparation Containing a Chitosan Salt
title_full Properties of an Oral Preparation Containing a Chitosan Salt
title_fullStr Properties of an Oral Preparation Containing a Chitosan Salt
title_full_unstemmed Properties of an Oral Preparation Containing a Chitosan Salt
title_short Properties of an Oral Preparation Containing a Chitosan Salt
title_sort properties of an oral preparation containing a chitosan salt
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253835/
https://www.ncbi.nlm.nih.gov/pubmed/19223823
http://dx.doi.org/10.3390/molecules14020755
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