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Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom

Around 20,000 snakebites are reported annually in Brazil and 90% of them are inflicted by species of the genus Bothrops. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reac...

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Autores principales: Nishijima, Catarine Massucato, Rodrigues, Clenilson Martins, Silva, Marcelo Aparecido, Lopes-Ferreira, Mônica, Vilegas, Wagner, Hiruma-Lima, Clélia Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253879/
https://www.ncbi.nlm.nih.gov/pubmed/19305361
http://dx.doi.org/10.3390/molecules14031072
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author Nishijima, Catarine Massucato
Rodrigues, Clenilson Martins
Silva, Marcelo Aparecido
Lopes-Ferreira, Mônica
Vilegas, Wagner
Hiruma-Lima, Clélia Akiko
author_facet Nishijima, Catarine Massucato
Rodrigues, Clenilson Martins
Silva, Marcelo Aparecido
Lopes-Ferreira, Mônica
Vilegas, Wagner
Hiruma-Lima, Clélia Akiko
author_sort Nishijima, Catarine Massucato
collection PubMed
description Around 20,000 snakebites are reported annually in Brazil and 90% of them are inflicted by species of the genus Bothrops. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reactions, a context that drives the search for complementary treatments for snakebite accidents. Vegetable extracts with a range of antiophidian activities constitute an excellent alternative. In this study, we investigated the anti-hemorrhagic effects of Mouriri pusa Gardn. (Melastomataceae), Byrsonima crassa Niedenzu (Malpighiaceae), Davilla elliptica St. Hill. (Dilleniaceae) and Strychnos pseudoquina St. Hil. (Loganiaceae) against Bothrops jararaca venom. The methanolic extracts from M. pusa (leaves), B. crassa (leaves) and D. elliptica (leaves) showed total neutralization capacity against local hemorrhages. The amenthoflavone and quercetin fractions from B. crassa and the flavonoids fractions (quercetin and myricetin) from M. pusa and D. elliptica also showed total neutralization capacity. We conclude that flavonoids derived from myricetin, quercetin and amenthoflavone play an important role in the anti-hemorrhagic potential of these Brazilian vegetables species against B. jararaca venom.
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spelling pubmed-62538792018-11-30 Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom Nishijima, Catarine Massucato Rodrigues, Clenilson Martins Silva, Marcelo Aparecido Lopes-Ferreira, Mônica Vilegas, Wagner Hiruma-Lima, Clélia Akiko Molecules Article Around 20,000 snakebites are reported annually in Brazil and 90% of them are inflicted by species of the genus Bothrops. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reactions, a context that drives the search for complementary treatments for snakebite accidents. Vegetable extracts with a range of antiophidian activities constitute an excellent alternative. In this study, we investigated the anti-hemorrhagic effects of Mouriri pusa Gardn. (Melastomataceae), Byrsonima crassa Niedenzu (Malpighiaceae), Davilla elliptica St. Hill. (Dilleniaceae) and Strychnos pseudoquina St. Hil. (Loganiaceae) against Bothrops jararaca venom. The methanolic extracts from M. pusa (leaves), B. crassa (leaves) and D. elliptica (leaves) showed total neutralization capacity against local hemorrhages. The amenthoflavone and quercetin fractions from B. crassa and the flavonoids fractions (quercetin and myricetin) from M. pusa and D. elliptica also showed total neutralization capacity. We conclude that flavonoids derived from myricetin, quercetin and amenthoflavone play an important role in the anti-hemorrhagic potential of these Brazilian vegetables species against B. jararaca venom. Molecular Diversity Preservation International 2009-03-09 /pmc/articles/PMC6253879/ /pubmed/19305361 http://dx.doi.org/10.3390/molecules14031072 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Nishijima, Catarine Massucato
Rodrigues, Clenilson Martins
Silva, Marcelo Aparecido
Lopes-Ferreira, Mônica
Vilegas, Wagner
Hiruma-Lima, Clélia Akiko
Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
title Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
title_full Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
title_fullStr Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
title_full_unstemmed Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
title_short Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
title_sort anti-hemorrhagic activity of four brazilian vegetable species against bothrops jararaca venom
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253879/
https://www.ncbi.nlm.nih.gov/pubmed/19305361
http://dx.doi.org/10.3390/molecules14031072
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