2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies

The Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is an important cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites. The discovery of new FP-2 inhibitors is now a hot topic in the search for potential malaria treatments. In this study, a series...

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Detalles Bibliográficos
Autores principales: Zhu, Jin, Chen, Tong, Chen, Lili, Lu, Weiqiang, Che, Peng, Huang, Jin, Li, Honglin, Li, Jian, Jiang, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253880/
https://www.ncbi.nlm.nih.gov/pubmed/19158658
http://dx.doi.org/10.3390/molecules14010494

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