A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their struc...

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Detalles Bibliográficos
Autores principales: Wang, Zhan Chang, Lin, Yi Ming, Feng, Dan Qin, Ke, Cai Huan, Lin, Peng, Yan, Chong Ling, Chen, Jun De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253882/
https://www.ncbi.nlm.nih.gov/pubmed/19158653
http://dx.doi.org/10.3390/molecules14010414
Descripción
Sumario:A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC(50) value of 0.54 ± 0.01 ppm.

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