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Vitamin B6: A Long Known Compound of Surprising Complexity

In recent years vitamin B6 has become a focus of research describing the compound’s critical function in cellular metabolism and stress response. For many years the sole function of vitamin B6 was considered to be that of an enzymatic cofactor. However, recently it became clear that it is also a pot...

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Autores principales: Mooney, Sutton, Leuendorf, Jan-Erik, Hendrickson, Christopher, Hellmann, Hanjo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253932/
https://www.ncbi.nlm.nih.gov/pubmed/19145213
http://dx.doi.org/10.3390/molecules14010329
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author Mooney, Sutton
Leuendorf, Jan-Erik
Hendrickson, Christopher
Hellmann, Hanjo
author_facet Mooney, Sutton
Leuendorf, Jan-Erik
Hendrickson, Christopher
Hellmann, Hanjo
author_sort Mooney, Sutton
collection PubMed
description In recent years vitamin B6 has become a focus of research describing the compound’s critical function in cellular metabolism and stress response. For many years the sole function of vitamin B6 was considered to be that of an enzymatic cofactor. However, recently it became clear that it is also a potent antioxidant that effectively quenches reactive oxygen species and is thus of high importance for cellular well-being. In view of the recent findings, the current review takes a look back and summarizes the discovery of vitamin B6 and the elucidation of its structure and biosynthetic pathways. It provides a detailed overview on vitamin B6 both as a cofactor and a protective compound. Besides these general characteristics of the vitamin, the review also outlines the current literature on vitamin B6 derivatives and elaborates on recent findings that provide new insights into transport and catabolism of the compound and on its impact on human health.
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spelling pubmed-62539322018-11-30 Vitamin B6: A Long Known Compound of Surprising Complexity Mooney, Sutton Leuendorf, Jan-Erik Hendrickson, Christopher Hellmann, Hanjo Molecules Review In recent years vitamin B6 has become a focus of research describing the compound’s critical function in cellular metabolism and stress response. For many years the sole function of vitamin B6 was considered to be that of an enzymatic cofactor. However, recently it became clear that it is also a potent antioxidant that effectively quenches reactive oxygen species and is thus of high importance for cellular well-being. In view of the recent findings, the current review takes a look back and summarizes the discovery of vitamin B6 and the elucidation of its structure and biosynthetic pathways. It provides a detailed overview on vitamin B6 both as a cofactor and a protective compound. Besides these general characteristics of the vitamin, the review also outlines the current literature on vitamin B6 derivatives and elaborates on recent findings that provide new insights into transport and catabolism of the compound and on its impact on human health. Molecular Diversity Preservation International 2009-01-12 /pmc/articles/PMC6253932/ /pubmed/19145213 http://dx.doi.org/10.3390/molecules14010329 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Mooney, Sutton
Leuendorf, Jan-Erik
Hendrickson, Christopher
Hellmann, Hanjo
Vitamin B6: A Long Known Compound of Surprising Complexity
title Vitamin B6: A Long Known Compound of Surprising Complexity
title_full Vitamin B6: A Long Known Compound of Surprising Complexity
title_fullStr Vitamin B6: A Long Known Compound of Surprising Complexity
title_full_unstemmed Vitamin B6: A Long Known Compound of Surprising Complexity
title_short Vitamin B6: A Long Known Compound of Surprising Complexity
title_sort vitamin b6: a long known compound of surprising complexity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253932/
https://www.ncbi.nlm.nih.gov/pubmed/19145213
http://dx.doi.org/10.3390/molecules14010329
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