Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis

In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respect...

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Detalles Bibliográficos
Autores principales: Yang, Ji-Guo, Liu, Ben-Guo, Liang, Gui-Zhao, Ning, Zheng-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253939/
https://www.ncbi.nlm.nih.gov/pubmed/19104485
http://dx.doi.org/10.3390/molecules14010046
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author Yang, Ji-Guo
Liu, Ben-Guo
Liang, Gui-Zhao
Ning, Zheng-Xiang
author_facet Yang, Ji-Guo
Liu, Ben-Guo
Liang, Gui-Zhao
Ning, Zheng-Xiang
author_sort Yang, Ji-Guo
collection PubMed
description In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respectively. The role of conjugated hydroxyl groups of the B and C ring is discussed. By using the following descriptors: ΔH(f) (the difference in heat of formation between flavonoids and their free radicals resulted after hydrogen atom donation) and H(BC) (the number of conjugated hydroxyl groups of the B and C ring), the result obtained in the antioxidant Rancimat test could be successfully explained.
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spelling pubmed-62539392018-11-30 Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis Yang, Ji-Guo Liu, Ben-Guo Liang, Gui-Zhao Ning, Zheng-Xiang Molecules Communication In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respectively. The role of conjugated hydroxyl groups of the B and C ring is discussed. By using the following descriptors: ΔH(f) (the difference in heat of formation between flavonoids and their free radicals resulted after hydrogen atom donation) and H(BC) (the number of conjugated hydroxyl groups of the B and C ring), the result obtained in the antioxidant Rancimat test could be successfully explained. Molecular Diversity Preservation International 2008-12-23 /pmc/articles/PMC6253939/ /pubmed/19104485 http://dx.doi.org/10.3390/molecules14010046 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Yang, Ji-Guo
Liu, Ben-Guo
Liang, Gui-Zhao
Ning, Zheng-Xiang
Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis
title Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis
title_full Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis
title_fullStr Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis
title_full_unstemmed Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis
title_short Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis
title_sort structure-activity relationship of flavonoids active against lard oil oxidation based on quantum chemical analysis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253939/
https://www.ncbi.nlm.nih.gov/pubmed/19104485
http://dx.doi.org/10.3390/molecules14010046
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AT liubenguo structureactivityrelationshipofflavonoidsactiveagainstlardoiloxidationbasedonquantumchemicalanalysis
AT liangguizhao structureactivityrelationshipofflavonoidsactiveagainstlardoiloxidationbasedonquantumchemicalanalysis
AT ningzhengxiang structureactivityrelationshipofflavonoidsactiveagainstlardoiloxidationbasedonquantumchemicalanalysis

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