Synthesis of 5-Substituted 3-Amino-1H-Pyrazole-4-Carbonitriles as Precursors for Microwave Assisted Regiospecific Syntheses of Pyrazolo[1,5-a]Pyrimidines

A simple route to 3-oxoalkanonitrile 5, a precursor of the title compounds is described. Reaction of enaminones 2 with hydroxylamine hydrochloride in ethanol yielded aldoximes 3 that were converted readily into 5 in basic medium. This method has been successfully applied with a number of substrates...

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Detalles Bibliográficos
Autores principales: Al-Qalaf, Fawzia, Mandani, Faisal, Abdelkhalik, Mervat Mohammed, Bassam, Abeer Abdulrahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253954/
https://www.ncbi.nlm.nih.gov/pubmed/19127239
http://dx.doi.org/10.3390/molecules14010078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253954/
https://www.ncbi.nlm.nih.gov/pubmed/19127239
http://dx.doi.org/10.3390/molecules14010078

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