2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation

The cysteine protease falcipain-2 (FP-2) of Plasmodium falciparum is a principal cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites, making it become an attractive target enzyme for developing anti-malarial drugs. In this study, a series of novel small molecu...

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Detalles Bibliográficos
Autores principales: Zhu, Jin, Chen, Tong, Liu, Jie, Ma, Ruoqun, Lu, Weiqiang, Huang, Jin, Li, Honglin, Li, Jian, Jiang, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253991/
https://www.ncbi.nlm.nih.gov/pubmed/19223827
http://dx.doi.org/10.3390/molecules14020785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253991/
https://www.ncbi.nlm.nih.gov/pubmed/19223827
http://dx.doi.org/10.3390/molecules14020785

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