Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened fo...

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Autores principales: Xu, Yi-Sheng, Zeng, Cheng-Chu, Jiao, Zi-Guo, Hu, Li-Ming, Zhong, Ru-gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254011/
https://www.ncbi.nlm.nih.gov/pubmed/19255545
http://dx.doi.org/10.3390/molecules14020868
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author Xu, Yi-Sheng
Zeng, Cheng-Chu
Jiao, Zi-Guo
Hu, Li-Ming
Zhong, Ru-gang
author_facet Xu, Yi-Sheng
Zeng, Cheng-Chu
Jiao, Zi-Guo
Hu, Li-Ming
Zhong, Ru-gang
author_sort Xu, Yi-Sheng
collection PubMed
description 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
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spelling pubmed-62540112018-11-30 Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives Xu, Yi-Sheng Zeng, Cheng-Chu Jiao, Zi-Guo Hu, Li-Ming Zhong, Ru-gang Molecules Article 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity. Molecular Diversity Preservation International 2009-01-19 /pmc/articles/PMC6254011/ /pubmed/19255545 http://dx.doi.org/10.3390/molecules14020868 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xu, Yi-Sheng
Zeng, Cheng-Chu
Jiao, Zi-Guo
Hu, Li-Ming
Zhong, Ru-gang
Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
title Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
title_full Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
title_fullStr Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
title_full_unstemmed Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
title_short Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
title_sort design, synthesis and anti-hiv integrase evaluation of 4-oxo-4h-quinolizine-3-carboxylic acid derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254011/
https://www.ncbi.nlm.nih.gov/pubmed/19255545
http://dx.doi.org/10.3390/molecules14020868
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