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2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients
BACKGROUND: Mycobaterium haemophilum has emerged as one of nontuberculous mycobacteria which caused localized and disseminated infections in immunocompromised patients. Infections caused by this pathogen were rarely diagnosed and reported because it can grow only in heme supplemented culture media....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254025/ http://dx.doi.org/10.1093/ofid/ofy210.1921 |
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author | Nookeu, Pornboonya Phoompoung, Pakpoom Foongladda, Suporn |
author_facet | Nookeu, Pornboonya Phoompoung, Pakpoom Foongladda, Suporn |
author_sort | Nookeu, Pornboonya |
collection | PubMed |
description | BACKGROUND: Mycobaterium haemophilum has emerged as one of nontuberculous mycobacteria which caused localized and disseminated infections in immunocompromised patients. Infections caused by this pathogen were rarely diagnosed and reported because it can grow only in heme supplemented culture media. METHODS: We performed a case–control study at Siriraj hospital, the biggest tertiary care hospital in Thailand, to determine the clinical difference and treatment outcome of this infection between HIV-infected and non-HIV-infected individuals. RESULTS: From January 2012 to December 2017, there were 21 patients diagnosed with Mycobacterium haemophilum infections. Eight of them were HIV infected. Rest of the patients were non-HIV immunocompromised which SLE was the most common comorbidities (autoimmune diseases 6 patients, anti-IFN gamma auto Ab 2 patients, kidney transplant recipients 2 patients, diabetes mellitus 2 patients and nephrotic syndrome 1 patient). The most common clinical manifestation was cutaneous involvement (13 patients, 61.9%). The result revealed that HIV-infected patients were much younger in comparison with non-HIV-infected patients (mean age 39 ± 10 VS. 52 ± 14 years; P = 0.025). Disseminated infection was more common in HIV-infected patients (37.5% vs. 15.4%, P = 0.325) and three of eight HIV-infected patients (37.5%) had central nervous system involvement whereas none of non-HIV infected patients had it (P = 0.042). The prognosis was slightly worse in HIV-infected individuals (Unfavorable prognosis 27.5% in HIV-infected VS. 15.4% in non-HIV-infected patients; P = 0.325). CONCLUSION: HIV infection is the most common immunocompromised condition related with Mycobacterium haemophilum infection. Central nervous system involvement is more common in HIV-infected patients. DISCLOSURES: All authors: No reported disclosures. |
format | Online Article Text |
id | pubmed-6254025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62540252018-11-28 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients Nookeu, Pornboonya Phoompoung, Pakpoom Foongladda, Suporn Open Forum Infect Dis Abstracts BACKGROUND: Mycobaterium haemophilum has emerged as one of nontuberculous mycobacteria which caused localized and disseminated infections in immunocompromised patients. Infections caused by this pathogen were rarely diagnosed and reported because it can grow only in heme supplemented culture media. METHODS: We performed a case–control study at Siriraj hospital, the biggest tertiary care hospital in Thailand, to determine the clinical difference and treatment outcome of this infection between HIV-infected and non-HIV-infected individuals. RESULTS: From January 2012 to December 2017, there were 21 patients diagnosed with Mycobacterium haemophilum infections. Eight of them were HIV infected. Rest of the patients were non-HIV immunocompromised which SLE was the most common comorbidities (autoimmune diseases 6 patients, anti-IFN gamma auto Ab 2 patients, kidney transplant recipients 2 patients, diabetes mellitus 2 patients and nephrotic syndrome 1 patient). The most common clinical manifestation was cutaneous involvement (13 patients, 61.9%). The result revealed that HIV-infected patients were much younger in comparison with non-HIV-infected patients (mean age 39 ± 10 VS. 52 ± 14 years; P = 0.025). Disseminated infection was more common in HIV-infected patients (37.5% vs. 15.4%, P = 0.325) and three of eight HIV-infected patients (37.5%) had central nervous system involvement whereas none of non-HIV infected patients had it (P = 0.042). The prognosis was slightly worse in HIV-infected individuals (Unfavorable prognosis 27.5% in HIV-infected VS. 15.4% in non-HIV-infected patients; P = 0.325). CONCLUSION: HIV infection is the most common immunocompromised condition related with Mycobacterium haemophilum infection. Central nervous system involvement is more common in HIV-infected patients. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2018-11-26 /pmc/articles/PMC6254025/ http://dx.doi.org/10.1093/ofid/ofy210.1921 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Abstracts Nookeu, Pornboonya Phoompoung, Pakpoom Foongladda, Suporn 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients |
title | 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients |
title_full | 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients |
title_fullStr | 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients |
title_full_unstemmed | 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients |
title_short | 2268. Clinical Difference of Mycobacterium haemophilum Infections Between HIV and Non-HIV-Infected Patients |
title_sort | 2268. clinical difference of mycobacterium haemophilum infections between hiv and non-hiv-infected patients |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254025/ http://dx.doi.org/10.1093/ofid/ofy210.1921 |
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