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Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts

Two new flavonol glycosides, myricetin 4'-O-α-l-rhamnopyranoside (1) and quercetin 3'-O-α-l-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-l-(1)C(4)-rhamnopyranoside (5), quercitri...

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Autores principales: Marzouk, Mohamed S., Moharram, Fatma A., Dib, Rabab A. El, El-Shenawy, Siham M., Tawfike, Ahmed F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254166/
https://www.ncbi.nlm.nih.gov/pubmed/19384277
http://dx.doi.org/10.3390/molecules14041456
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author Marzouk, Mohamed S.
Moharram, Fatma A.
Dib, Rabab A. El
El-Shenawy, Siham M.
Tawfike, Ahmed F.
author_facet Marzouk, Mohamed S.
Moharram, Fatma A.
Dib, Rabab A. El
El-Shenawy, Siham M.
Tawfike, Ahmed F.
author_sort Marzouk, Mohamed S.
collection PubMed
description Two new flavonol glycosides, myricetin 4'-O-α-l-rhamnopyranoside (1) and quercetin 3'-O-α-l-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-l-(1)C(4)-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-β-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg(-1)b.wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin (4) and hyperin (7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay.
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spelling pubmed-62541662018-11-30 Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts Marzouk, Mohamed S. Moharram, Fatma A. Dib, Rabab A. El El-Shenawy, Siham M. Tawfike, Ahmed F. Molecules Article Two new flavonol glycosides, myricetin 4'-O-α-l-rhamnopyranoside (1) and quercetin 3'-O-α-l-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-l-(1)C(4)-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-β-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg(-1)b.wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin (4) and hyperin (7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay. Molecular Diversity Preservation International (MDPI) 2009-04-07 /pmc/articles/PMC6254166/ /pubmed/19384277 http://dx.doi.org/10.3390/molecules14041456 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Marzouk, Mohamed S.
Moharram, Fatma A.
Dib, Rabab A. El
El-Shenawy, Siham M.
Tawfike, Ahmed F.
Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts
title Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts
title_full Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts
title_fullStr Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts
title_full_unstemmed Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts
title_short Polyphenolic Profile and Bioactivity Study of Oenothera speciosa Nutt. Aerial Parts
title_sort polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254166/
https://www.ncbi.nlm.nih.gov/pubmed/19384277
http://dx.doi.org/10.3390/molecules14041456
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