A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt

A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixtu...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yanhong, Hu, Zhen, Meng, Xiangli, Jing, Jiehui, Song, Yuanjun, Zhang, Chunhua, Huang, Yudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254206/
https://www.ncbi.nlm.nih.gov/pubmed/19471189
http://dx.doi.org/10.3390/molecules14051652
Descripción
Sumario:A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H(2)/Pd/C/C(2)H(5)OH system was developed. The products were characterized by TG, IR, (1)H-NMR, (13)C-NMR, HPLC and elemental analysis.

Ejemplares similares