A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt

A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixtu...

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Detalles Bibliográficos
Autores principales: Wang, Yanhong, Hu, Zhen, Meng, Xiangli, Jing, Jiehui, Song, Yuanjun, Zhang, Chunhua, Huang, Yudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254206/
https://www.ncbi.nlm.nih.gov/pubmed/19471189
http://dx.doi.org/10.3390/molecules14051652
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author Wang, Yanhong
Hu, Zhen
Meng, Xiangli
Jing, Jiehui
Song, Yuanjun
Zhang, Chunhua
Huang, Yudong
author_facet Wang, Yanhong
Hu, Zhen
Meng, Xiangli
Jing, Jiehui
Song, Yuanjun
Zhang, Chunhua
Huang, Yudong
author_sort Wang, Yanhong
collection PubMed
description A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H(2)/Pd/C/C(2)H(5)OH system was developed. The products were characterized by TG, IR, (1)H-NMR, (13)C-NMR, HPLC and elemental analysis.
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spelling pubmed-62542062018-11-30 A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt Wang, Yanhong Hu, Zhen Meng, Xiangli Jing, Jiehui Song, Yuanjun Zhang, Chunhua Huang, Yudong Molecules Article A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H(2)/Pd/C/C(2)H(5)OH system was developed. The products were characterized by TG, IR, (1)H-NMR, (13)C-NMR, HPLC and elemental analysis. Molecular Diversity Preservation International 2009-04-27 /pmc/articles/PMC6254206/ /pubmed/19471189 http://dx.doi.org/10.3390/molecules14051652 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Yanhong
Hu, Zhen
Meng, Xiangli
Jing, Jiehui
Song, Yuanjun
Zhang, Chunhua
Huang, Yudong
A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
title A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
title_full A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
title_fullStr A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
title_full_unstemmed A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
title_short A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
title_sort simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254206/
https://www.ncbi.nlm.nih.gov/pubmed/19471189
http://dx.doi.org/10.3390/molecules14051652
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