Phenoxypropylamines: Synthesis and Antiulcer Evaluation

We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activit...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Zhang, Bao-Yan, Zhang, Qian-Yun, Zhao, Dong-Mei, Wang, Jia-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254222/
https://www.ncbi.nlm.nih.gov/pubmed/19471202
http://dx.doi.org/10.3390/molecules14051818
Descripción
Sumario:We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of them showed significant gastric acid antisecretory activity.

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