Phenoxypropylamines: Synthesis and Antiulcer Evaluation

We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activit...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Zhang, Bao-Yan, Zhang, Qian-Yun, Zhao, Dong-Mei, Wang, Jia-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254222/
https://www.ncbi.nlm.nih.gov/pubmed/19471202
http://dx.doi.org/10.3390/molecules14051818
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author Zhang, Hui
Zhang, Bao-Yan
Zhang, Qian-Yun
Zhao, Dong-Mei
Wang, Jia-Mei
author_facet Zhang, Hui
Zhang, Bao-Yan
Zhang, Qian-Yun
Zhao, Dong-Mei
Wang, Jia-Mei
author_sort Zhang, Hui
collection PubMed
description We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of them showed significant gastric acid antisecretory activity.
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spelling pubmed-62542222018-11-30 Phenoxypropylamines: Synthesis and Antiulcer Evaluation Zhang, Hui Zhang, Bao-Yan Zhang, Qian-Yun Zhao, Dong-Mei Wang, Jia-Mei Molecules Communication We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of them showed significant gastric acid antisecretory activity. Molecular Diversity Preservation International 2009-05-13 /pmc/articles/PMC6254222/ /pubmed/19471202 http://dx.doi.org/10.3390/molecules14051818 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Zhang, Hui
Zhang, Bao-Yan
Zhang, Qian-Yun
Zhao, Dong-Mei
Wang, Jia-Mei
Phenoxypropylamines: Synthesis and Antiulcer Evaluation
title Phenoxypropylamines: Synthesis and Antiulcer Evaluation
title_full Phenoxypropylamines: Synthesis and Antiulcer Evaluation
title_fullStr Phenoxypropylamines: Synthesis and Antiulcer Evaluation
title_full_unstemmed Phenoxypropylamines: Synthesis and Antiulcer Evaluation
title_short Phenoxypropylamines: Synthesis and Antiulcer Evaluation
title_sort phenoxypropylamines: synthesis and antiulcer evaluation
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254222/
https://www.ncbi.nlm.nih.gov/pubmed/19471202
http://dx.doi.org/10.3390/molecules14051818
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AT zhangqianyun phenoxypropylaminessynthesisandantiulcerevaluation
AT zhaodongmei phenoxypropylaminessynthesisandantiulcerevaluation
AT wangjiamei phenoxypropylaminessynthesisandantiulcerevaluation

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