Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of P...

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Autores principales: Malek, Sri Nurestri Abdul, Shin, Sim Kae, Wahab, Norhanom Abdul, Yaacob, Hashim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254274/
https://www.ncbi.nlm.nih.gov/pubmed/19471192
http://dx.doi.org/10.3390/molecules14051713
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author Malek, Sri Nurestri Abdul
Shin, Sim Kae
Wahab, Norhanom Abdul
Yaacob, Hashim
author_facet Malek, Sri Nurestri Abdul
Shin, Sim Kae
Wahab, Norhanom Abdul
Yaacob, Hashim
author_sort Malek, Sri Nurestri Abdul
collection PubMed
description Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC(50 )value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.
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spelling pubmed-62542742018-11-30 Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves Malek, Sri Nurestri Abdul Shin, Sim Kae Wahab, Norhanom Abdul Yaacob, Hashim Molecules Article Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC(50 )value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo. Molecular Diversity Preservation International 2009-05-06 /pmc/articles/PMC6254274/ /pubmed/19471192 http://dx.doi.org/10.3390/molecules14051713 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Malek, Sri Nurestri Abdul
Shin, Sim Kae
Wahab, Norhanom Abdul
Yaacob, Hashim
Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
title Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
title_full Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
title_fullStr Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
title_full_unstemmed Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
title_short Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves
title_sort cytotoxic components of pereskia bleo (kunth) dc. (cactaceae) leaves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254274/
https://www.ncbi.nlm.nih.gov/pubmed/19471192
http://dx.doi.org/10.3390/molecules14051713
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AT wahabnorhanomabdul cytotoxiccomponentsofpereskiableokunthdccactaceaeleaves
AT yaacobhashim cytotoxiccomponentsofpereskiableokunthdccactaceaeleaves

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