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Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system

Oxidative stress triggers and exacerbates neurodegeneration in Alzheimer's disease (AD). Various antioxidants reduce oxidative stress, but these agents have little efficacy due to poor blood–brain barrier (BBB) permeability. Additionally, single-modal antioxidants are easily overwhelmed by glob...

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Detalles Bibliográficos
Autores principales:	Murphy, Kelsey, Llewellyn, Killian, Wakser, Samuel, Pontasch, Josef, Samanich, Natasha, Flemer, Matthew, Hensley, Kenneth, Kim, Dong-Shik, Park, Joshua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254342/ https://www.ncbi.nlm.nih.gov/pubmed/30282635 http://dx.doi.org/10.1074/jbc.RA117.001245

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