Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations

Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. We now report application of a practical alkylation procedure to several quinazolinedio...

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Detalles Bibliográficos
Autores principales: Rivero, Ignacio Alfredo, Guerrero, Leticia, Espinoza, Karla Alejandra, Meza, Martha Cecilia, Rodríguez, Jesús Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254370/
https://www.ncbi.nlm.nih.gov/pubmed/19471206
http://dx.doi.org/10.3390/molecules14051860
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author Rivero, Ignacio Alfredo
Guerrero, Leticia
Espinoza, Karla Alejandra
Meza, Martha Cecilia
Rodríguez, Jesús Ramón
author_facet Rivero, Ignacio Alfredo
Guerrero, Leticia
Espinoza, Karla Alejandra
Meza, Martha Cecilia
Rodríguez, Jesús Ramón
author_sort Rivero, Ignacio Alfredo
collection PubMed
description Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1‑methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.
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spelling pubmed-62543702018-11-30 Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations Rivero, Ignacio Alfredo Guerrero, Leticia Espinoza, Karla Alejandra Meza, Martha Cecilia Rodríguez, Jesús Ramón Molecules Article Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1‑methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations. Molecular Diversity Preservation International 2009-05-20 /pmc/articles/PMC6254370/ /pubmed/19471206 http://dx.doi.org/10.3390/molecules14051860 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rivero, Ignacio Alfredo
Guerrero, Leticia
Espinoza, Karla Alejandra
Meza, Martha Cecilia
Rodríguez, Jesús Ramón
Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
title Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
title_full Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
title_fullStr Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
title_full_unstemmed Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
title_short Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
title_sort alkylation of 2,4-(1h,3h)-quinazolinediones with dialkyl carbonates under microwave irradiations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254370/
https://www.ncbi.nlm.nih.gov/pubmed/19471206
http://dx.doi.org/10.3390/molecules14051860
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