Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense

Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most activ...

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Detalles Bibliográficos
Autores principales: Laphookhieo, Surat, Maneerat, Wisanu, Koysomboon, Sorwaporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254373/
https://www.ncbi.nlm.nih.gov/pubmed/19384270
http://dx.doi.org/10.3390/molecules14041389
Descripción
Sumario:Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 μg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 μg/mL.

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