Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense

Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most activ...

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Autores principales: Laphookhieo, Surat, Maneerat, Wisanu, Koysomboon, Sorwaporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254373/
https://www.ncbi.nlm.nih.gov/pubmed/19384270
http://dx.doi.org/10.3390/molecules14041389
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author Laphookhieo, Surat
Maneerat, Wisanu
Koysomboon, Sorwaporn
author_facet Laphookhieo, Surat
Maneerat, Wisanu
Koysomboon, Sorwaporn
author_sort Laphookhieo, Surat
collection PubMed
description Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 μg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 μg/mL.
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spelling pubmed-62543732018-11-30 Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense Laphookhieo, Surat Maneerat, Wisanu Koysomboon, Sorwaporn Molecules Article Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 μg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 μg/mL. Molecular Diversity Preservation International (MDPI) 2009-03-30 /pmc/articles/PMC6254373/ /pubmed/19384270 http://dx.doi.org/10.3390/molecules14041389 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Laphookhieo, Surat
Maneerat, Wisanu
Koysomboon, Sorwaporn
Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense
title Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense
title_full Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense
title_fullStr Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense
title_full_unstemmed Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense
title_short Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense
title_sort antimalarial and cytotoxic phenolic compounds from cratoxylum maingayi and cratoxylum cochinchinense
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254373/
https://www.ncbi.nlm.nih.gov/pubmed/19384270
http://dx.doi.org/10.3390/molecules14041389
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