Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importa...

Descripción completa

Detalles Bibliográficos
Autores principales: Neto, Brenno A. D., Lapis, Alexandre A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254398/
https://www.ncbi.nlm.nih.gov/pubmed/19471193
http://dx.doi.org/10.3390/molecules14051725
_version_ 1783373706330898432
author Neto, Brenno A. D.
Lapis, Alexandre A. M.
author_facet Neto, Brenno A. D.
Lapis, Alexandre A. M.
author_sort Neto, Brenno A. D.
collection PubMed
description In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.
format Online
Article
Text
id pubmed-6254398
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-62543982018-11-30 Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends Neto, Brenno A. D. Lapis, Alexandre A. M. Molecules Review In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described. Molecular Diversity Preservation International 2009-05-07 /pmc/articles/PMC6254398/ /pubmed/19471193 http://dx.doi.org/10.3390/molecules14051725 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Neto, Brenno A. D.
Lapis, Alexandre A. M.
Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
title Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
title_full Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
title_fullStr Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
title_full_unstemmed Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
title_short Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
title_sort recent developments in the chemistry of deoxyribonucleic acid (dna) intercalators: principles, design, synthesis, applications and trends
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254398/
https://www.ncbi.nlm.nih.gov/pubmed/19471193
http://dx.doi.org/10.3390/molecules14051725
work_keys_str_mv AT netobrennoad recentdevelopmentsinthechemistryofdeoxyribonucleicaciddnaintercalatorsprinciplesdesignsynthesisapplicationsandtrends
AT lapisalexandream recentdevelopmentsinthechemistryofdeoxyribonucleicaciddnaintercalatorsprinciplesdesignsynthesisapplicationsandtrends

Ejemplares similares