Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu

INTRODUCTION: The role of tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6 in the pathogenicity of seasonal flu is unknown. METHODS: We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-ti...

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Autores principales: Ramos, José M., García-Navarro, Mar, Moreno, Victoria, González-de-la-Aleja, Pilar, Gimeno-Gascón, Adelina, Merino, Esperanza, Portilla, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Quimioterapia 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254480/
https://www.ncbi.nlm.nih.gov/pubmed/30421883
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author Ramos, José M.
García-Navarro, Mar
Moreno, Victoria
González-de-la-Aleja, Pilar
Gimeno-Gascón, Adelina
Merino, Esperanza
Portilla, Joaquín
author_facet Ramos, José M.
García-Navarro, Mar
Moreno, Victoria
González-de-la-Aleja, Pilar
Gimeno-Gascón, Adelina
Merino, Esperanza
Portilla, Joaquín
author_sort Ramos, José M.
collection PubMed
description INTRODUCTION: The role of tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6 in the pathogenicity of seasonal flu is unknown. METHODS: We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction). RESULTS: Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza CONCLUSION: IL-6 levels were lower in adults with influenza.
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spelling pubmed-62544802018-12-11 Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu Ramos, José M. García-Navarro, Mar Moreno, Victoria González-de-la-Aleja, Pilar Gimeno-Gascón, Adelina Merino, Esperanza Portilla, Joaquín Rev Esp Quimioter Brief Report INTRODUCTION: The role of tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6 in the pathogenicity of seasonal flu is unknown. METHODS: We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction). RESULTS: Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza CONCLUSION: IL-6 levels were lower in adults with influenza. Sociedad Española de Quimioterapia 2018-11-23 2018-12 /pmc/articles/PMC6254480/ /pubmed/30421883 Text en © The Author 2018 https://creativecommons.org/licenses/by-nc/4.0/ The article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Brief Report
Ramos, José M.
García-Navarro, Mar
Moreno, Victoria
González-de-la-Aleja, Pilar
Gimeno-Gascón, Adelina
Merino, Esperanza
Portilla, Joaquín
Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
title Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
title_full Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
title_fullStr Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
title_full_unstemmed Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
title_short Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
title_sort interleukin (il) -1 β, il-6 and tumor necrosis factor in patients with seasonal flu
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254480/
https://www.ncbi.nlm.nih.gov/pubmed/30421883
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