777. Ten-Year Experience of Tertiary Hospital Regarding Epidemiology, Diagnostic Method, and Drug Resistance of Tuberculosis—Jeddah, Saudi Arabia

BACKGROUND: The prevalence of tuberculosis across Saudi Arabia is variable with western provinces have the highest incidence. This study aimed to determine the epidemiology of tuberculosis in Jeddah, the age and gender distribution and the accuracy of conventional diagnostic method, for better understanding of tuberculosis-resistant pattern in the country. METHODS: Three hundred forty-four culture proven tuberculosis where collected from November 2006 to November 2016 in KFSHRC. AFB smear and nucleic acid amplification test (NAAT) were conducted in all positive cultures, and all data were analyzed using SPSS. Mean days number to culture positivity was 12.79. RESULTS: TB showed young age predominant (59.5%) compared with older population (37.0%) and pediatrics (3.5%), with 55.4% males and 44.6% females, 54.8% of samples were taken from pulmonary and 45.2% from extra pulmonary site of infection. 68.3% and 5.9% of the tuberculosis proven culture were negative by using AFB smear and NAAT, respectively, and only 68.8% were positive for mycobacterium tuberculosis complex by using NAAT. Resistant level to first-line anti tuberculosis of 12.5%, 10.3%, 5.2%, 2.6%, 1.3%, 2.6% to Streptomycin, isoniazid, pyrazinamide, Rifampicin, Ethambutol and multidrug-resistant, respectively, was observed in our study. CONCLUSION: Young age predominance, high values of negative smear and NAAT increased incidence of extra pulmonary site of infection and Re-emergence of tuberculosis resistant which was observed in our study compared with previous national surveys (Illustrated in Figure 1), all should alter physicians’ Attention when investigating patients in Saudi Arabia and high clinical suspicion should be considered. [Image: see text] DISCLOSURES: All authors: No reported disclosures.