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Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells

Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases (HDACs) such as 5-Aza-CdR and FK228 has shown to enhance cytotoxic activities of several...

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Detalles Bibliográficos
Autores principales:	Park, Jong Kook, Seo, Jung Seon, Lee, Suk Kyeong, Chan, Kenneth K, Kuh, Hyo-Jeong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254647/ https://www.ncbi.nlm.nih.gov/pubmed/30173503 http://dx.doi.org/10.4062/biomolther.2018.061

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