Cargando…

707. Clarifying the Role of CrrB in Polymxyin-resistant Klebsiella pneumoniae Clinical Isolates Utilizing a Novel CRISPR-Cas9 System

BACKGROUND: Polymyxin resistance (PR) threatens the mainstay of therapy for carbapenem-resistant Enterobacteriaceae (CRE) infections. While mgrB disruption accounts for most cases of PR, missense mutations in crrB have been proposed as an alternative pathway for PR through PmrA/B/C upregulation of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	McConville, Thomas, Giddins, Marla, Macesic, Nenad, Uhlemann, Anne-Catrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254691/ http://dx.doi.org/10.1093/ofid/ofy210.714

Ejemplares similares

CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae
por: McConville, Thomas H., et al.
Publicado: (2020)

An efficient and versatile CRISPR-Cas9 system for genetic manipulation of multi-drug resistant Klebsiella pneumoniae
por: McConville, Thomas H., et al.
Publicado: (2021)

A putative RND-type efflux pump, H239_3064, contributes to colistin resistance through CrrB in Klebsiella pneumoniae
por: Cheng, Yi-Hsiang, et al.
Publicado: (2018)

Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae
por: Wang, Yanfei, et al.
Publicado: (2023)

A cyclic adenosine monophosphate response element-binding protein inhibitor enhances the antibacterial activity of polymyxin B by inhibiting the ATP hydrolyzation activity of CrrB
por: Huang, Wei, et al.
Publicado: (2022)

Multidrug-Resistant Klebsiella pneumoniae ST307 in Traveler Returning from Puerto Rico to Dominican Republic
por: Rojas, Rita, et al.
Publicado: (2019)

Predicting Phenotypic Polymyxin Resistance in Klebsiella pneumoniae through Machine Learning Analysis of Genomic Data
por: Macesic, Nenad, et al.
Publicado: (2020)

CrrAB regulates PagP-mediated glycerophosphoglycerol palmitoylation in the outer membrane of Klebsiella pneumoniae
por: Sun, Lang, et al.
Publicado: (2022)

Genomic and Geographic Context for the Evolution of High-Risk Carbapenem-Resistant Enterobacter cloacae Complex Clones ST171 and ST78
por: Gomez-Simmonds, Angela, et al.
Publicado: (2018)

Structures of the rat complement regulator CrrY
por: Roversi, Pietro, et al.
Publicado: (2011)

Colonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation
por: Annavajhala, Medini K., et al.
Publicado: (2019)

An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection
por: Ahn, Danielle, et al.
Publicado: (2021)

Peritoneal Dialysis-Related Peritonitis With Carbapenem-Resistant Klebsiella pneumoniae and Vancomycin-Resistant Enterococcus faecium
por: Moso, Michael A, et al.
Publicado: (2021)

Association of CRISPR/Cas System with the Drug Resistance in Klebsiella pneumoniae
por: Wang, Gang, et al.
Publicado: (2020)

CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
por: Mackow, Natalie A., et al.
Publicado: (2019)

CRISPR-Cas System in Antibiotic Resistance Plasmids in Klebsiella pneumoniae
por: Kamruzzaman, Muhammad, et al.
Publicado: (2020)

Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance
por: Bowden, Anne Ramsay, et al.
Publicado: (2020)

1249. Emergence of Diverse Carbapenem-Resistant Enterobacteriaceae (CRE) in the Dominican Republic
por: Fermin, Rita Rojas, et al.
Publicado: (2018)

Carbapenem-resistant Enterobacteriaceae colonization (CRE) and subsequent risk of infection and 90-day mortality in critically ill patients, an observational study
por: McConville, Thomas Howe, et al.
Publicado: (2017)

2306. Molecular Epidemiology of and Risk Factors for Staphyloccus aureus (SA) Colonization in a Chinese Neonatal Intensive Care Unit (NICU)
por: Geng, Wenjing, et al.
Publicado: (2018)

Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
por: Gomez-Simmonds, Angela, et al.
Publicado: (2022)

371. Cluster of carbapenemase-producing Enterobacterales secondary infections during the COVID-19 crisis at a New York City hospital
por: Gomez-Simmonds, Angela, et al.
Publicado: (2020)

Staphylococcus epidermidis Protection Against Staphylococcus aureus Colonization in People Living With Human Immunodeficiency Virus in an Inner-City Outpatient Population: A Cross-Sectional Study
por: Sullivan, Sean B., et al.
Publicado: (2016)

Imipenem represses CRISPR-Cas interference of DNA acquisition through H-NS stimulation in Klebsiella pneumoniae
por: Lin, Tzu-Lung, et al.
Publicado: (2016)

Exploiting a conjugative endogenous CRISPR-Cas3 system to tackle multidrug-resistant Klebsiella pneumoniae
por: Zhou, Ying, et al.
Publicado: (2023)

Epidemiology of Staphylococcus aureus in neonates on admission to a Chinese neonatal intensive care unit
por: Geng, Wenjing, et al.
Publicado: (2020)

PacCYP707A2 negatively regulates cherry fruit ripening while PacCYP707A1 mediates drought tolerance
por: Li, Qian, et al.
Publicado: (2015)

Characterization of CRISPR-Cas Systems in Clinical Klebsiella pneumoniae Isolates Uncovers Its Potential Association With Antibiotic Susceptibility
por: Li, Hsin-Yu, et al.
Publicado: (2018)

Survey of clustered regularly interspaced short palindromic repeats and their associated Cas proteins (CRISPR/Cas) systems in multiple sequenced strains of Klebsiella pneumoniae
por: Ostria-Hernández, Martha Lorena, et al.
Publicado: (2015)

707. Molecular Epidemiology of Clostridioides difficile Colonization in Families with Infants
por: Toltzis, Philip, et al.
Publicado: (2023)

Identification of a Novel Response Regulator, Crr1, That Is Required for Hydrogen Peroxide Resistance in Candida albicans
por: Bruce, Catherine R., et al.
Publicado: (2011)

A CRR2-Dependent sRNA Sequence Supports Papillomavirus Vaccine Expression in Tobacco Chloroplasts
por: Legen, Julia, et al.
Publicado: (2023)

P473: CRISPR/CAS9 GENE EDITING CLARIFIES THE ROLE OF CD33 SNP RS12459419 IN GEMTUZUMAB OZOGAMICIN-MEDIATED CYTOTOXICITY
por: Oya, Shuki, et al.
Publicado: (2023)

The type I-E CRISPR-Cas system influences the acquisition of bla(KPC)-IncF plasmid in Klebsiella pneumonia
por: Zhou, Ying, et al.
Publicado: (2020)

Enhancing the capability of Klebsiella pneumoniae to produce 1, 3‐propanediol by overexpression and regulation through CRISPR‐dCas9
por: Wang, Xin, et al.
Publicado: (2022)

Detection of Klebsiella pneumonia DNA and ESBL positive strains by PCR-based CRISPR-LbCas12a system
por: Wang, Shang, et al.
Publicado: (2023)

MiR-182 regulates cell proliferation and apoptosis in laryngeal squamous cell carcinoma by targeting the CRR9
por: Lv, Yuan, et al.
Publicado: (2019)

PT707. Transcriptome analysis in Tsc2 heterozygous knockout mice
por: Kasai, Shinya, et al.
Publicado: (2016)

707. QPX9003: Pharmacology of a Novel Polymyxin in Mice and Rats
por: Sabet, Mojgan, et al.
Publicado: (2019)

707. Infective Endocarditis and Medication Assisted Treatment in Opioid Use Disorder
por: Loomis, Katherine, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1gdh39ah87hkddf1kcohn8uqg1