Coupling Reactions of α-Bromocarboxylate with Non-Aromatic N-Heterocycles ‡

The conditions for the C-N bond forming reaction (C-N coupling reaction) between α-bromocarboxylate and nitrogen-containing non-aromatic heterocyclic rings under heterogeneous copper(I) oxide catalysis are investigated in this paper. All the generated compounds were fully characterized by IR, NMR an...

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Detalles Bibliográficos
Autores principales: Brychtova, Katerina, Slaba, Barbora, Placek, Lukas, Jampilek, Josef, Raich, Ivan, Csollei, Jozef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254713/
https://www.ncbi.nlm.nih.gov/pubmed/19701142
http://dx.doi.org/10.3390/molecules14083019
Descripción
Sumario:The conditions for the C-N bond forming reaction (C-N coupling reaction) between α-bromocarboxylate and nitrogen-containing non-aromatic heterocyclic rings under heterogeneous copper(I) oxide catalysis are investigated in this paper. All the generated compounds were fully characterized by IR, NMR and MS spectroscopy. Ab initio/DFT calculations of partial charges on nitrogen atoms in all the discussed heterocycles and on C((2)) of carboxylate under applied conditions were predicted. These in silico results correlate relatively with the experimental observations.

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