Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives

Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were...

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Autores principales: Pau, Amedeo, Murineddu, Gabriele, Asproni, Battistina, Murruzzu, Caterina, Grella, Giuseppe E., Pinna, Gérard A., Curzu, Maria M., Marchesi, Irene, Bagella, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254715/
https://www.ncbi.nlm.nih.gov/pubmed/19783939
http://dx.doi.org/10.3390/molecules14093494
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author Pau, Amedeo
Murineddu, Gabriele
Asproni, Battistina
Murruzzu, Caterina
Grella, Giuseppe E.
Pinna, Gérard A.
Curzu, Maria M.
Marchesi, Irene
Bagella, Luigi
author_facet Pau, Amedeo
Murineddu, Gabriele
Asproni, Battistina
Murruzzu, Caterina
Grella, Giuseppe E.
Pinna, Gérard A.
Curzu, Maria M.
Marchesi, Irene
Bagella, Luigi
author_sort Pau, Amedeo
collection PubMed
description Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
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spelling pubmed-62547152018-11-30 Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives Pau, Amedeo Murineddu, Gabriele Asproni, Battistina Murruzzu, Caterina Grella, Giuseppe E. Pinna, Gérard A. Curzu, Maria M. Marchesi, Irene Bagella, Luigi Molecules Article Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively. Molecular Diversity Preservation International 2009-09-09 /pmc/articles/PMC6254715/ /pubmed/19783939 http://dx.doi.org/10.3390/molecules14093494 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pau, Amedeo
Murineddu, Gabriele
Asproni, Battistina
Murruzzu, Caterina
Grella, Giuseppe E.
Pinna, Gérard A.
Curzu, Maria M.
Marchesi, Irene
Bagella, Luigi
Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
title Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
title_full Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
title_fullStr Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
title_full_unstemmed Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
title_short Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
title_sort synthesis and cytotoxicity of novel hexahydrothieno-cycloheptapyridazinone derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254715/
https://www.ncbi.nlm.nih.gov/pubmed/19783939
http://dx.doi.org/10.3390/molecules14093494
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