Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents

A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedi...

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Detalles Bibliográficos
Autores principales: Huang, Conghai, Meng, Xiangbao, Cui, Jingrong, Li, Zhongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254791/
https://www.ncbi.nlm.nih.gov/pubmed/19633615
http://dx.doi.org/10.3390/molecules14072447
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author Huang, Conghai
Meng, Xiangbao
Cui, Jingrong
Li, Zhongjun
author_facet Huang, Conghai
Meng, Xiangbao
Cui, Jingrong
Li, Zhongjun
author_sort Huang, Conghai
collection PubMed
description A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.
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spelling pubmed-62547912018-11-30 Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents Huang, Conghai Meng, Xiangbao Cui, Jingrong Li, Zhongjun Molecules Article A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity. Molecular Diversity Preservation International 2009-07-08 /pmc/articles/PMC6254791/ /pubmed/19633615 http://dx.doi.org/10.3390/molecules14072447 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Conghai
Meng, Xiangbao
Cui, Jingrong
Li, Zhongjun
Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
title Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
title_full Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
title_fullStr Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
title_full_unstemmed Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
title_short Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents
title_sort synthesis of 3-n-sugar-substituted-2, 4(1h, 3h)-quinazolinediones as anti-angiogenesis agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254791/
https://www.ncbi.nlm.nih.gov/pubmed/19633615
http://dx.doi.org/10.3390/molecules14072447
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AT cuijingrong synthesisof3nsugarsubstituted241h3hquinazolinedionesasantiangiogenesisagents
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