2314. Invasive Haemophilus influenzae Infections in Children: A 10-Year Study

BACKGROUND: The rate of Haemophilus influenzae type b (HIB) infections has decreased dramatically since the use of HIB vaccines in infants and children. The current prevalence of invasive HIB infections and those due to non-type b H. influenzae is not fully known. The objective was to describe the cases of all invasive H. influenzae infections and describe the spectrum and severity of clinical disease. METHODS: Retrospective study of all hospitalized patients with culture-proven invasive Haemophilus influenzae infections at Nationwide Children’s Hospital, Columbus, Ohio, from 2009 to 2018. The electronic health records were reviewed for pertinent demographic, clinical, laboratory data, and outcomes. RESULTS: There were a total of 59 culture-proven H. influenzae infections of which 12 were excluded due to insufficient patient data. The remaining 47 patients (32 [68%] male; 30 [64%] white, 8 [17%] African-American) and their culture results are provided in Table: There were 14 (30%) patients with pneumonia and bacteremia, 6 (13%) with meningitis and bacteremia, 2 (4%) with only meningitis, 1 (2%) with bacteremia/meningitis and septic hip, 2 (4%) septic arthritis with bacteremia, 1 (2%) with periorbital cellulitis and bacteremia, and 21 (45%) with only bacteremia. Of the 3 cases of H. influenzae type b, 2 had not been vaccinated while 1 received only 1 dose of HIB vaccine. CONCLUSION: Invasive H. influenzae infections were associated with substantial morbidity and a 2% case-fatality rate. DISCLOSURES: All authors: No reported disclosures.