Squalene Emulsions for Parenteral Vaccine and Drug Delivery

Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing em...

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Detalles Bibliográficos
Autor principal: Fox, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254918/
https://www.ncbi.nlm.nih.gov/pubmed/19783926
http://dx.doi.org/10.3390/molecules14093286
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author Fox, Christopher B.
author_facet Fox, Christopher B.
author_sort Fox, Christopher B.
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description Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.
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spelling pubmed-62549182018-11-30 Squalene Emulsions for Parenteral Vaccine and Drug Delivery Fox, Christopher B. Molecules Review Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined. Molecular Diversity Preservation International 2009-09-01 /pmc/articles/PMC6254918/ /pubmed/19783926 http://dx.doi.org/10.3390/molecules14093286 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Fox, Christopher B.
Squalene Emulsions for Parenteral Vaccine and Drug Delivery
title Squalene Emulsions for Parenteral Vaccine and Drug Delivery
title_full Squalene Emulsions for Parenteral Vaccine and Drug Delivery
title_fullStr Squalene Emulsions for Parenteral Vaccine and Drug Delivery
title_full_unstemmed Squalene Emulsions for Parenteral Vaccine and Drug Delivery
title_short Squalene Emulsions for Parenteral Vaccine and Drug Delivery
title_sort squalene emulsions for parenteral vaccine and drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254918/
https://www.ncbi.nlm.nih.gov/pubmed/19783926
http://dx.doi.org/10.3390/molecules14093286
work_keys_str_mv AT foxchristopherb squaleneemulsionsforparenteralvaccineanddrugdelivery

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