Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety

New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazid...

Descripción completa

Detalles Bibliográficos
Autores principales: Moise, Mihaela, Sunel, Valeriu, Profire, Lenuta, Popa, Marcel, Desbrieres, Jacques, Peptu, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254919/
https://www.ncbi.nlm.nih.gov/pubmed/19633628
http://dx.doi.org/10.3390/molecules14072621
_version_ 1783373837186891776
author Moise, Mihaela
Sunel, Valeriu
Profire, Lenuta
Popa, Marcel
Desbrieres, Jacques
Peptu, Cristian
author_facet Moise, Mihaela
Sunel, Valeriu
Profire, Lenuta
Popa, Marcel
Desbrieres, Jacques
Peptu, Cristian
author_sort Moise, Mihaela
collection PubMed
description New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the anti-inflammatory study of the triazole compound 9 established an appreciable anti-inflammatory activity that is comparable with that of other nonsteroidal anti-inflammatory agents.
format Online
Article
Text
id pubmed-6254919
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-62549192018-11-30 Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety Moise, Mihaela Sunel, Valeriu Profire, Lenuta Popa, Marcel Desbrieres, Jacques Peptu, Cristian Molecules Article New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the anti-inflammatory study of the triazole compound 9 established an appreciable anti-inflammatory activity that is comparable with that of other nonsteroidal anti-inflammatory agents. Molecular Diversity Preservation International 2009-07-16 /pmc/articles/PMC6254919/ /pubmed/19633628 http://dx.doi.org/10.3390/molecules14072621 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Moise, Mihaela
Sunel, Valeriu
Profire, Lenuta
Popa, Marcel
Desbrieres, Jacques
Peptu, Cristian
Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_full Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_fullStr Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_full_unstemmed Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_short Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_sort synthesis and biological activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254919/
https://www.ncbi.nlm.nih.gov/pubmed/19633628
http://dx.doi.org/10.3390/molecules14072621
work_keys_str_mv AT moisemihaela synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
AT sunelvaleriu synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
AT profirelenuta synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
AT popamarcel synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
AT desbrieresjacques synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
AT peptucristian synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety

Ejemplares similares