Antimalarial Activity of Ultra-Short Peptides †

Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC(50) data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium ber...

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Autores principales: Pérez-Picaso, Lemuel, Velasco-Bejarano, Benjamín, Aguilar-Guadarrama, A. Berenice, Argotte-Ramos, Rocío, Rios, María Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254971/
https://www.ncbi.nlm.nih.gov/pubmed/20032878
http://dx.doi.org/10.3390/molecules14125103
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author Pérez-Picaso, Lemuel
Velasco-Bejarano, Benjamín
Aguilar-Guadarrama, A. Berenice
Argotte-Ramos, Rocío
Rios, María Yolanda
author_facet Pérez-Picaso, Lemuel
Velasco-Bejarano, Benjamín
Aguilar-Guadarrama, A. Berenice
Argotte-Ramos, Rocío
Rios, María Yolanda
author_sort Pérez-Picaso, Lemuel
collection PubMed
description Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC(50) data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC(50) values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.
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spelling pubmed-62549712018-11-30 Antimalarial Activity of Ultra-Short Peptides † Pérez-Picaso, Lemuel Velasco-Bejarano, Benjamín Aguilar-Guadarrama, A. Berenice Argotte-Ramos, Rocío Rios, María Yolanda Molecules Article Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC(50) data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC(50) values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations. Molecular Diversity Preservation International 2009-12-08 /pmc/articles/PMC6254971/ /pubmed/20032878 http://dx.doi.org/10.3390/molecules14125103 Text en © 2009 by the authors licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pérez-Picaso, Lemuel
Velasco-Bejarano, Benjamín
Aguilar-Guadarrama, A. Berenice
Argotte-Ramos, Rocío
Rios, María Yolanda
Antimalarial Activity of Ultra-Short Peptides †
title Antimalarial Activity of Ultra-Short Peptides †
title_full Antimalarial Activity of Ultra-Short Peptides †
title_fullStr Antimalarial Activity of Ultra-Short Peptides †
title_full_unstemmed Antimalarial Activity of Ultra-Short Peptides †
title_short Antimalarial Activity of Ultra-Short Peptides †
title_sort antimalarial activity of ultra-short peptides †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254971/
https://www.ncbi.nlm.nih.gov/pubmed/20032878
http://dx.doi.org/10.3390/molecules14125103
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