Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues

Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addre...

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Detalles Bibliográficos
Autores principales: Kojima, Naoto, Tanaka, Tetsuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254973/
https://www.ncbi.nlm.nih.gov/pubmed/19783948
http://dx.doi.org/10.3390/molecules14093621
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author Kojima, Naoto
Tanaka, Tetsuaki
author_facet Kojima, Naoto
Tanaka, Tetsuaki
author_sort Kojima, Naoto
collection PubMed
description Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.
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spelling pubmed-62549732018-11-30 Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues Kojima, Naoto Tanaka, Tetsuaki Molecules Review Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues. Molecular Diversity Preservation International 2009-09-17 /pmc/articles/PMC6254973/ /pubmed/19783948 http://dx.doi.org/10.3390/molecules14093621 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kojima, Naoto
Tanaka, Tetsuaki
Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
title Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
title_full Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
title_fullStr Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
title_full_unstemmed Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
title_short Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
title_sort medicinal chemistry of annonaceous acetogenins: design, synthesis, and biological evaluation of novel analogues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254973/
https://www.ncbi.nlm.nih.gov/pubmed/19783948
http://dx.doi.org/10.3390/molecules14093621
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