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545. Rational Design of Doravirine (DOR): A Review of Development From Bench to Patients
BACKGROUND: First-generation NNRTIs with nucleoside reverse transcriptase inhibitors are effective in sustaining HIV-1 suppression but development of resistant mutants is often seen in patients whose regimens fail. These NNRTIs are also associated with safety/tolerability issues, such as CNS and ras...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254998/ http://dx.doi.org/10.1093/ofid/ofy210.553 |