Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles

Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffracti...

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Detalles Bibliográficos
Autores principales: Bakavoli, Mehdi, Beyzaie, Hamid, Rahimizadeh, Mohammad, Eshghi, Hossein, Takjoo, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255026/
https://www.ncbi.nlm.nih.gov/pubmed/20032863
http://dx.doi.org/10.3390/molecules14114849
Descripción
Sumario:Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles 5a-g.

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