Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles

Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffracti...

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Autores principales: Bakavoli, Mehdi, Beyzaie, Hamid, Rahimizadeh, Mohammad, Eshghi, Hossein, Takjoo, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255026/
https://www.ncbi.nlm.nih.gov/pubmed/20032863
http://dx.doi.org/10.3390/molecules14114849
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author Bakavoli, Mehdi
Beyzaie, Hamid
Rahimizadeh, Mohammad
Eshghi, Hossein
Takjoo, Reza
author_facet Bakavoli, Mehdi
Beyzaie, Hamid
Rahimizadeh, Mohammad
Eshghi, Hossein
Takjoo, Reza
author_sort Bakavoli, Mehdi
collection PubMed
description Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles 5a-g.
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spelling pubmed-62550262018-11-30 Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles Bakavoli, Mehdi Beyzaie, Hamid Rahimizadeh, Mohammad Eshghi, Hossein Takjoo, Reza Molecules Article Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles 5a-g. Molecular Diversity Preservation International 2009-11-25 /pmc/articles/PMC6255026/ /pubmed/20032863 http://dx.doi.org/10.3390/molecules14114849 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bakavoli, Mehdi
Beyzaie, Hamid
Rahimizadeh, Mohammad
Eshghi, Hossein
Takjoo, Reza
Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
title Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
title_full Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
title_fullStr Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
title_full_unstemmed Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
title_short Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
title_sort regioselective synthesis of new 2-(e)-cyano(thiazolidin-2-ylidene)thiazoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255026/
https://www.ncbi.nlm.nih.gov/pubmed/20032863
http://dx.doi.org/10.3390/molecules14114849
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